CBD vs. CBG vs. CBN: What’s the Difference and What Should You Use?

A European Perspective on the Most Popular Non-Intoxicating Cannabinoids

As the cannabinoid wellness space continues to evolve in Malta and across Europe, consumers are encountering new terms beyond the familiar CBD particularly CBG and CBN. While all three are naturally occurring compounds from the cannabis plant, their effects, legal classifications, and applications differ in meaningful ways.

In this guide, we break down the key differences between CBD, CBG, and CBN, including how they interact with the body, which one may be best for your needs, and what’s legally and commercially available in Malta and EU-regulated markets.

What Are Cannabinoids?

Cannabinoids are bioactive compounds found in the cannabis and hemp plants. These molecules interact with the endocannabinoid system (ECS) i.e. a regulatory network in the human body that helps maintain balance in areas such as sleep, mood, immune response, and pain.

While over 100 cannabinoids have been identified, CBD (cannabidiol), CBG (cannabigerol), and CBN (cannabinol) have gained popularity for their distinct properties and non-intoxicating profiles.

CBD: The Foundational Cannabinoid

CBD is by far the most researched and widely used non-intoxicating cannabinoid. It’s extracted primarily from EU-certified industrial hemp, making it compliant with Maltese and EU law when containing under 0.2% THC.

Key Benefits of CBD

• Supports stress relief and emotional balance

• May reduce inflammation and discomfort

• Aids in sleep regulation and overall wellness

• Widely available in oils, capsules, creams, and vapes

CBD works indirectly with ECS receptors, promoting homeostasis without binding directly like THC. Its safety profile is well-established, and several products, including FDA-approved medications, validate its therapeutic potential.

✅ CBD is ideal for daily use and general wellness.

CBG: The “Mother Cannabinoid” with Potential for Focus and Gut Health

CBG is often called the precursor or “stem cell” cannabinoid because it transforms into other cannabinoids (like CBD and THC) as the plant matures. This makes it harder to extract, hence more expensive and less common, but interest in CBG is growing rapidly.

Emerging Benefits of CBG

• May support mental clarity and focus

• Studied for anti-inflammatory and neuroprotective effects

• May benefit digestive health and gut inflammation

• Often paired with CBD in daytime-focused formulas

Although clinical studies are in early stages, animal and preclinical trials show promising results for CBG’s role in supporting the central nervous system and cognition.

✅ CBG is best suited for daytime use, focus, and clarity.

CBN: The Restful Cannabinoid Often Associated with Sleep

CBN is formed when THC breaks down over time — not through synthetic alteration, but via natural oxidation. It has mild relaxation properties in very high doses, but in legal hemp-derived formulations (under 0.2% THC), it is considered non-intoxicating.

Potential Benefits of CBN

• Commonly associated with sleep and deep relaxation

• May support muscle recovery and nighttime calm

• Works synergistically with CBD in full-spectrum products

• May contribute to the entourage effect (cannabinoid synergy)

Although CBN alone may not be a strong sedative, it often enhances the relaxing effects of CBD or other cannabinoids in nighttime blends.

✅ CBN is best used in the evening to promote restful sleep.

Comparison Table: CBD vs. CBG vs. CBN

Choosing the Right Cannabinoid for You

Your ideal cannabinoid depends on your individual goals. Here’s a quick guide

• For general balance and stress relief: Start with a high-quality CBD oil or capsule.

• For focus or productivity: Try CBD + CBG blends in a morning or midday routine.

• For sleep support or evening relaxation: Look for products combining CBD and CBN, preferably broad-spectrum or full-spectrum for maximum effect.

At Cannabis Clinics Malta, we stock a range of third-party tested cannabinoid products, including CBD oils, broad-spectrum capsules, and CBN-enhanced night formulas. Whether you're new to cannabinoids or exploring advanced options, our team can guide you toward a safe and effective choice.

Cannabinoid Use in Malta: What You Need to Know

All cannabinoid-based products sold in Malta must comply with strict EU regulations:

• Must be hemp-derived

• THC content must not exceed 0.2%

• Products cannot make medical claims unless licensed as medicinal

We work only with trusted European suppliers, ensuring that every product on our shelves is legal, tested, and safe for public use in Malta and the EU.

Final Thoughts: Do You Need One, Two, or All Three?

CBD, CBG, and CBN each have unique benefits, but they’re often most powerful when combined in a thoughtfully formulated product. Thanks to the entourage effect, using cannabinoids together may offer a broader spectrum of wellness benefits.

Whether you’re looking to manage stress, sharpen focus, or improve your sleep, Cannabis Clinics Malta is here to help. Visit us online or in-store to learn more about our full-spectrum and cannabinoid-specific products, and feel free to contact our expert team with any questions.